FAVIPIRAVIR 200mg TABLETS

FAVIPIRAVIR 200mg TABLETS

 

Fabiflu is an antiviral medicine. Fabiflu is used for the treatment of Influenza. Fabiflu is a pyrazine carboxamide derivative like (T-1105 & T-1106). Fabiflu is also being studied and used to treat a number of other viral infections. It became a common drug.

Mechanism of action:

The mechanism of action is thought to be combined with the selective inhibition of viral RNA-dependent RNA polymerase. Other research suggests that Fabiflu induces lethal RNA transversion mutations, producing an unwise viral phenotype. Fabiflu is a prodrug that is used to metabolize an active form, Fabiflu-ribofuranosyl-5'-triphosphate (Fabiflu-RTP), available in both oral and intravenous formulations. Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is treated to play a key role in this activation process. Fabiflu does not prevent RNA or DNA synthesis in mammalian cells and is not toxic to them. However, Fabiflu has not been shown to be active in primary human airway cells, casting doubt on its potency in influenza treatment.

Drug Interaction

Fabiflu inhibited irreversibly AO in a dose and time-dependent manner and inhibited CYP2C8 in a dose-dependent manner. There was no inhibitory action to XO, and weak inhibitory movement to CYP1A2. The hydroxylase metabolite showed weak inhibitory action to CYP1A2. Inductive effect of Fabiflu on CYP was not recognized.

PHARMACOKINETICS

1. Absorption

       When Fabiflu was given as a single dose of 400 mg with food, the Cmax reduced. It develops that Fabiflu is given at a higher dose or in multiple doses, irreversible inhibition of aldehyde oxidase (AO) appear and the effect of food on the Cmax is lower.

2. Distribution

         Fabiflu is an antibody protein binding ratio was 53.4 to 54.4% (Centrifugal ultrafiltration) at 0.3 - 30 μg/ml.

3. Metabolism

   Fabiflu was not metabolized by cytochrome P-450 (CYP), mainly metabolized by aldehyde oxidase (AO), and slightly metabolized to a hydroxylated form by xanthine oxidase (XO).

4. Excretion

Fabiflu was mainly secreted as a hydroxylated form into the urine 0.8% and little amount of unaffected drug 53.1% was noticed. The half-life of Fabiflu is concluded to range from 2 to 5.5 hours.

Uses:

Fabiflu is determined for novel influenza (strains that cause more severe disease) rather than recurring influenza.

Side Effects:

Recommended not to use during pregnancy because its impairment to the baby

Contraindications

There are several contraindications when using Fabiflu tablets. In the history of patients is a hypersensitivity to any ingredient of a drug.

Pregnancy and Lactation

·        Fabiflu should not be used in a Pregnancy situation

·        No breastfeeding is suggested

Storage:

Fabiflu tablets capsule should be stocked at room temperature at below 30℃(86 ℉) Fabiflu container should be kept away from humidity, warmth, and sun

Dosage and Administration

The Common dose of Fabiflu for adults is 1600 mg orally twice in a day replace by 600 mg orally twice for 4 days. The total composition time should be for 5 days.

Contact details 

Apple Pharmaceuticals 

Mobile/Viber/Telegram:+919987711567

WeChat: applepharmaceuticals 

Skype: applepharma

qq: 2097734872

Email id:applepharmaceutical@gmail.com

FABIFLU 200MG TABLET

FABIFLU 200MG TABLET

 

Fabiflu is an antiviral medicine. Fabiflu is used for the treatment of Influenza. Fabiflu is a pyrazine carboxamide derivative like (T-1105 & T-1106). Fabiflu is also being studied and used to treat a number of other viral infections. It became a common drug.

Mechanism of action:

The mechanism of action is thought to be combined with the selective inhibition of viral RNA-dependent RNA polymerase. Other research suggests that Fabiflu induces lethal RNA transversion mutations, producing an unwise viral phenotype. Fabiflu is a prodrug that is used to metabolize an active form, Fabiflu-ribofuranosyl-5'-triphosphate (Fabiflu-RTP), available in both oral and intravenous formulations. Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is treated to play a key role in this activation process. Fabiflu does not prevent RNA or DNA synthesis in mammalian cells and is not toxic to them. However, Fabiflu has not been shown to be active in primary human airway cells, casting doubt on its potency in influenza treatment.

Drug Interaction

Fabiflu inhibited irreversibly AO in a dose and time-dependent manner and inhibited CYP2C8 in a dose-dependent manner. There was no inhibitory action to XO, and weak inhibitory movement to CYP1A2. The hydroxylase metabolite showed weak inhibitory action to CYP1A2. Inductive effect of Fabiflu on CYP was not recognized.

PHARMACOKINETICS

1. Absorption

       When Fabiflu was given as a single dose of 400 mg with food, the Cmax reduced. It develops that Fabiflu is given at a higher dose or in multiple doses, irreversible inhibition of aldehyde oxidase (AO) appear and the effect of food on the Cmax is lower.

2. Distribution

         Fabiflu is an antibody protein binding ratio was 53.4 to 54.4% (Centrifugal ultrafiltration) at 0.3 - 30 μg/ml.

3. Metabolism

   Fabiflu was not metabolized by cytochrome P-450 (CYP), mainly metabolized by aldehyde oxidase (AO), and slightly metabolized to a hydroxylated form by xanthine oxidase (XO).

4. Excretion

Fabiflu was mainly secreted as a hydroxylated form into the urine 0.8% and little amount of unaffected drug 53.1% was noticed. The half-life of Fabiflu is concluded to range from 2 to 5.5 hours.

Uses:

Fabiflu is determined for novel influenza (strains that cause more severe disease) rather than recurring influenza.

Side Effects:

Recommended not to use during pregnancy because its impairment to the baby

Contraindications

There are several contraindications when using Fabiflu tablets. In the history of patients is a hypersensitivity to any ingredient of a drug.

Pregnancy and Lactation

•           Fabiflu should not be used in a Pregnancy situation

•           No breastfeeding is suggested

Storage:

Fabiflu tablets capsule should be stocked at room temperature at below 30℃(86 ℉) Fabiflu container should be kept away from humidity, warmth, and sun

Dosage and Administration

The Common dose of Fabiflu for adults is 1600 mg orally twice in a day replace by 600 mg orally twice for 4 days. The total composition time should be for 5 days.

Contact details 

Apple Pharmaceuticals 

Mobile/Viber/Telegram:+919987711567

WeChat: applepharmaceuticals 

Skype: applepharma

qq: 2097734872

Email id:applepharmaceutical@gmail.com

AFANAT 20MG/30MG/40MG

AFANAT 20MG/30MG/40MG

FAVIVIR 200MG TABLETS

Favivir  200MG TABLETS

Favivir is an antiviral medicine. Favivir is used for the treatment of Influenza. Favivir is a pyrazine carboxamide derivative like (T-1105 & T-1106). Favivir is also being studied and used to treat a number of other viral infections. It became a common drug.

Mechanism of action:

The mechanism of action is thought to be combined with the selective inhibition of viral RNA-dependent RNA polymerase. Other research suggests that Favivir induces lethal RNA transversion mutations, producing an unwise viral phenotype. Favivir is a prodrug that is used to metabolize an active form, favipiravir-ribofuranosyl-5'-triphosphate (Favipiravir-RTP), available in both oral and intravenous formulations. Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is treated to play a key role in this activation process. Favivir does not prevent RNA or DNA synthesis in mammalian cells and is not toxic to them. However, Favivir has not been shown to be active in primary human airway cells, casting doubt on its potency in influenza treatment.

Drug Interaction

Favivir inhibited irreversibly AO in a dose and time-dependent manner and inhibited CYP2C8 in a dose-dependent manner. There was no inhibitory action to XO, and weak inhibitory movement to CYP1A2. The hydroxylase metabolite showed weak inhibitory action to CYP1A2. The inductive effect of Favivir on CYP was not recognized.

PHARMACOKINETICS

1. Absorption

When Favivir was given as a single dose of 400 mg with food, the Cmax reduced. It develops that Favivir is given at a higher dose or in multiple doses, irreversible inhibition of aldehyde oxidase (AO) appear and the effect of food on the Cmax is lower.

2. Distribution

Favivir is a the antibody-protein binding ratio was 53.4 to 54.4% (Centrifugal ultrafiltration) at 0.3 - 30 μg/ml.

3. Metabolism

Favivir was not metabolized by cytochrome P-450 (CYP), mainly metabolized by aldehyde oxidase (AO), and slightly metabolized to a hydroxylated form by xanthine oxidase (XO).

4. Excretion

Favivir was mainly secreted as a hydroxylated form into the urine 0.8% and little amount of unaffected drug 53.1% were noticed. The half-life of Favivir is concluded to range from 2 to 5.5 hours.

Uses:

Favivir is determined for novel influenza (strains that cause more severe disease) rather than recurring influenza.

Side Effects:

Recommended not to use during pregnancy because its impairment to the baby

Contraindications

There are several contraindications when using Favivir tablets. In the history of patients is a hypersensitivity to any ingredient of a drug.

Pregnancy and Lactation

·        Favivir should not be used in a Pregnancy situation

·        No breastfeeding is suggested

Storage:

Favivir tablets capsule should be stocked at room the temperature at below 30℃(86 ℉) Favivir container should be kept away from humidity, warmth, and sun

Dosage and Administration

The Common dose of Favivir for adults is 1600 mg orally twice in a day replace by 600 mg orally twice for 4 days. The total composition time should be for 5 days.

Contact details
Apple Pharmaceuticals
Mobile/Viber/Telegram :+919987711567
WeChat : applepharmaceuticals
Skype : applepharma
qq : 2097734872
Email id :applepharmaceutical@gmail.com
Website : https://myapplepharma.com/

FAVIVIR 200MG TABLETS

OCANAT 10mg

OCANAT 10mg 

OCANAT TABLET

Ocanat 5mg tablet is a semi-synthetic bile acid analog that has the chemical formation of 6α-ethyl-chenodeoxycholic acid. Ocanat 5mg tablet is used as a medicine to treatment basic biliary cholangitis and is sustain with growth for various other liver diseases and similar disorders.

Mechanism of action:

Primary biliary cirrhosis is an auto resistant action by which the bile ducts and liver are injured more, dominant to fibrosis and cirrhosis. Bile acids grow the risk of injury and fibrosis to the injured bile ducts. Ocanat 5mg tablet is an agonist for FXR, a nuclear receptor indicates in the liver and intestine. FXR is a key manager of bile acid, inflammatory, fibrotic, and metabolic pathways. FXR energizing loss of intracellular hepatocyte absorption of bile acids by overcoming de novo combining from cholesterol as well as by high transport of bile acids out of the hepatocytes.

Pharmacokinetics:

1. Absorption

Ocanat 5mg tablet is involved in the gastrointestinal tract. The Cmax of Ocanat 5mg tablet appears at almost 1.5 hours after an oral dose and domain from 28.8-53.7 ng/mL at doses of 5-10mg. The median Tmax for both has been combined with Ocanat 5mg tablet is about 10 hours.

2. Distribution

The volume of the distribution of Ocanat 5mg tablet is 618 L.

3. Metabolism

The metabolism of Ocanat 5mg tablet appears in the liver. Ocanat 5mg tablet is combined with glycine or taurine, followed by excretion into bile. The combines are then consumed in the small intestine and then re-enter the liver via enterohepatic distribution.

4. Excretion

About 87% of an orally administrate dose is supposed for in the feces. Less than 3% of the dose can be recovered in the urine.

The biological half-life of the Ocanat 5mg tablet is reported to be 24 hours.

Dosage and Administration:

The suggested starting dose of Ocanat 5mg tablet is 5 mg once weekly for patients with Child-Pugh Class B or C hepatic breakage or a previous decompensating action.

Drug Interaction:

Drug interactions may variation how your treatment effort or growth your risk for severe side effects.

Side-Effects:

·        Tiredness, 

·        Throat pain, or

·        Pounding heartbeat may appear,

·        Skin itching, 

·        Nausea,

·        Loss of appetite, 

·        Abdominal pain,

·        Yellowing eyes, 

·        Dark urine,

·        Joint pain,

·        Abdomen, or

·        Mental

Uses:

This treatment of Ocanat 5mg tablet is used apart or in mixture treatment for secure liver disease (primary biliary cholangitis-PBC). This infection gently damages the bile ducts in the liver.

Contraindication:

Ocanat 5mg tablet is contraindicated in patients with determining biliary impediment.

Adverse Reactions:

·        Hepatic Decompensating and breakdown in wrongly dosed PBC Patients with Child-Pugh Class B or C or Decompensated Cirrhosis

·        Liver-similar Adverse response

·        Serious Pruritus

·        Rebate in HDL-C

Storage:

Store at 20^oC-25^oC (68^oF-77^oF) a room temperature.

Contact details Apple Pharmaceuticals Mobile/Viber/Telegram :+919987711567WeChat : applepharmaceuticals Skype : applepharmaqq : 2097734872Email id :applepharmaceutical@gmail.comWebsite : https://myapplepharma.com/

Favivir 200MG TABLETS

Favivir  200MG TABLETS

Favivir is an antiviral medicine. Favivir is used for the treatment of Influenza. Favivir is a pyrazine carboxamide derivative like (T-1105 & T-1106). Favivir is also being studied and used to treat a number of other viral infections. It became a common drug.

Mechanism of action:

The mechanism of action is thought to be combined with the selective inhibition of viral RNA-dependent RNA polymerase. Other research suggests that Favivir induces lethal RNA transversion mutations, producing an unwise viral phenotype. Favivir is a prodrug that is used to metabolize an active form, favipiravir-ribofuranosyl-5'-triphosphate (Favipiravir-RTP), available in both oral and intravenous formulations. Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is treated to play a key role in this activation process. Favivir does not prevent RNA or DNA synthesis in mammalian cells and is not toxic to them. However, Favivir has not been shown to be active in primary human airway cells, casting doubt on its potency in influenza treatment.

Drug Interaction

Favivir inhibited irreversibly AO in a dose and time-dependent manner and inhibited CYP2C8 in a dose-dependent manner. There was no inhibitory action to XO, and weak inhibitory movement to CYP1A2. The hydroxylase metabolite showed weak inhibitory action to CYP1A2. The inductive effect of Favivir on CYP was not recognized.

PHARMACOKINETICS

1. Absorption

When Favivir was given as a single dose of 400 mg with food, the Cmax reduced. It develops that Favivir is given at a higher dose or in multiple doses, irreversible inhibition of aldehyde oxidase (AO) appear and the effect of food on the Cmax is lower.

2. Distribution

Favivir is a the antibody-protein binding ratio was 53.4 to 54.4% (Centrifugal ultrafiltration) at 0.3 - 30 μg/ml.

3. Metabolism

Favivir was not metabolized by cytochrome P-450 (CYP), mainly metabolized by aldehyde oxidase (AO), and slightly metabolized to a hydroxylated form by xanthine oxidase (XO).

4. Excretion

Favivir was mainly secreted as a hydroxylated form into the urine 0.8% and little amount of unaffected drug 53.1% were noticed. The half-life of Favivir is concluded to range from 2 to 5.5 hours.

Uses:

Favivir is determined for novel influenza (strains that cause more severe disease) rather than recurring influenza.

Side Effects:

Recommended not to use during pregnancy because its impairment to the baby

Contraindications

There are several contraindications when using Favivir tablets. In the history of patients is a hypersensitivity to any ingredient of a drug.

Pregnancy and Lactation

·        Favivir should not be used in a Pregnancy situation

·        No breastfeeding is suggested

Storage:

Favivir tablets capsule should be stocked at room the temperature at below 30℃(86 ℉) Favivir container should be kept away from humidity, warmth, and sun

Dosage and Administration

The Common dose of Favivir for adults is 1600 mg orally twice in a day replace by 600 mg orally twice for 4 days. The total composition time should be for 5 days.

Contact details
Apple Pharmaceuticals
Mobile/Viber/Telegram :+919987711567
WeChat : applepharmaceuticals
Skype : applepharma
qq : 2097734872
Email id :applepharmaceutical@gmail.com
Website : https://myapplepharma.com/

FAVIVIR 200MG