TAFNAT 25mg TABLET

TAFNAT25mg TABLET

Tafnat tablet is a hepatitis B virus (HBV) nucleotide reverse transcriptase inhibitor for the medication of chronic hepatitis B virus (HBV) infection in adults with recompense liver disease. Tafnat tablets taken by orally. Tenofovir alafenamide is a prodrug of tenofovir. Tafnat tablet approximately connected to the commonly used is reverse-transcriptase inhibitor tenofovir disoproxil fumarate (TDF).

Mechanism of action:

Tafnat tablet presents 91% lower plasma concentration with an intracellular being of about 20-fold higher when related to tenofovir disoproxil. Tafnat tablet acquires further in peripheral blood mononuclear cells related to red blood cells. Once stimulate, tenofovir acts with various systems contains the prevention of viral polymerase, being chain termination, and the blockage of viral synthesis.

Pharmacokinetics:

1. Absorption

Tafnat tablet presents a the lipophilic group that covers the negative charge of the person component which develops its oral bioavailability. Tafnat tablet is deeply stable in plasma and, after the organization of this prodrug; there is a low combination of tenofovir in plasma.

2.Distribution

The volume of distribution of Tafnat tablet was higher than 100 L.

3. Metabolism

Tafnat tablet is recommended to be determined to the person mixture tenofovir by the action of cathepsin A or carboxylesterase 1. Tenofovir alafenamide presents serious plasma establishment and hence, its awakening is performed inside the mark cells.

4.Excretion

Tafnat tablet has been certified to existing a bile expulsion that compares to 47% of the administrate dose and a renal elimination the represents about 36%. From the regained dose in urine, about 75% is represented as unaffected tenofovir followed by uric acid and a small dose of tenofovir alafenamide. In feces, 99% of the recovered dose compare to tenofovir.

Dosage and Administration

The suggested dosage of Tafnat tablet is 25 mg (one tablet) taken orally once daily with food.

Side-Effects:

Headache, Fatigue, Cough, Nausea, Back pain, Abdominal pain, Reduction in bone mineral density, Glycosuria, Creatine kinase elevation, Amylase lipase elevated.

Drug Interaction:

Drug interactions may change to your treatment work or increase your risk for severe side effects.

Uses:

Tafnat tablet is used to treat chronic hepatitis B infection, a viral infection of the liver.

Storage:

Store below 30 °C (86 °F). Keep the bottle tightly closed. Distribute only in the original bottle.

Over Dosage:

Treatment of overdosage with Tafnat tablet consists of a general accessory portion containing monitoring of vital signs as well as consideration of the clinical status of the patient. Tafnat is clearly removed by hemodialysis with an eradication coefficient of almost 54%.

Missed Dose:

If you missed a dose and remember within 18 hours after the scheduled time, take it as soon as you remind. If it is longer than 18 hours after the missed dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

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