VIROPIL TABLET

VIROPIL TABLET

Viropil is a drug used to treat HIV/AIDS. Viropil is a mixture of Dolutegravir, lamivudine, and tenofovir disoproxil. The human immunodeficiency virus (HIV) multiplies in cells of the resistant organization and damages them. Without proper medication, the immune system of most HIV patients is tired so much over an era that they convert actively diseased.

Mechanism of action:

Dolutegravir is an HIV-1 antiviral agent. Viropil prevents HIV integrase by covering to the effective place of activity and obstructing the string conduction step of retroviral DNA unification in performs cell. The string conduction step is a condition in the HIV reproduction cycle and development in the prevention of viral action. Lamivudine is an artificial nucleoside analog and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside parallel is included in viral DNA by HIV reverse transcriptase and HBV polymerase, developing in DNA chain termination. Tenofovir exists to consider antiretroviral medicine known as nucleotide analog reverse transcriptase inhibitors (NtRTIs), which prevent reverse transcriptase, an enzyme required for viral management in HIV-infected thing. This implements the administration of HIV viral load over reduce viral reproduction.

Pharmacokinetics:

1. Absorption

When 50 mg of Dolutegravir once every day was orally carried out to HIV-1 affect person, the AUC, Cmax, and Cmin is 53.6 mcg h/mL, 3.67mcg/mL, and 1.11mcg/mL, commonly. The peak plasma combination was recognized 2 to 3 hours post-dose. Lamivudine was immediately involved after oral administration in HIV-diseased patients. After oral carry out of tenofovir disoproxil to patients with HIV disease, tenofovir disoproxil is rapidly involved and metabolized to tenofovir.

2. Distribution

The conducting of a dose of 50 mg of Dolutegravir instant a seeming volume of distribution is 17.4 L. Volume of distribution was separated to dose and did not compare with body pressure. The volume of distribution at fixed-state is 1.3 ± 0.6 L/kg and 1.2 ± 0.4 L/kg, following intravenous direction of tenofovir 1.0 mg/kg and 3.0 mg/kg

3. Metabolism

Metabolism of lamivudine is an underage route of eradication. Dolutegravir is deeply metabolized over three main pathways and it forms no deep-aware metabolites. The first pathway is described by the glucuronidation by UGT1A1, the second pathway by carbon oxidation by CYP3A4 and the third pathway is what develops to be a subsequent oxidative defluorination and glutathione combination. Tenofovir disoproxil fumarate is the fumarate flavoring of the prodrug tenofovir disoproxil.

    4. Excretion

Dolutegravir is almost all total doses are recovered in a capacity of 53% excreted unaffected in the feces and 31% excreted in the urine. The mot of lamivudine is removed unchanged in the urine by the effective natural cationic flow. Tenofovir nearly 70–80% of the dose is found in the urine as constant tenofovir within 72 hours of treatment.

Side-Effects:

Viropil  is side effects that may contain trouble sleeping, weight gain, and rash.

Dosage and Administration:

Viropil  is a suggested dosage procedure of Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablets is one tablet once every day carried out.

Contraindication:

Viropil  is a Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablets are contraindicated in patients with preceding hypersensitivity response.

Storage:

Store in a Dry place Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablets in the original container, protect from humidity and keep the bottle tightly closed.

Pregnancy & Lactation:

There is a pregnancy uncovering archives that oversee pregnancy effect in women unprotected to Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablets during pregnancy

HIV-1 disease is not to breastfeed because HIV-1 can be developing to the baby in breast milk.

Contact details 
Apple Pharmaceuticals 
Mobile/Viber/Telegram :+919987711567
WeChat : applepharmaceuticals 
Skype : applepharma
qq : 2097734872
Email id:applepharmaceutical@gmail.com
Website : https://myapplepharma.com/