OCANAT TABLET

Ocanat 5mg tablet is a semi-synthetic bile acid analog that has the chemical formation of 6α-ethyl-chenodeoxycholic acid. Ocanat 5mg tablet is used as a medicine to treatment basic biliary cholangitis and is sustain with growth for various other liver diseases and similar disorders.

Mechanism of action:

Primary biliary cirrhosis is an auto resistant action by which the bile ducts and liver are injured more, dominant to fibrosis and cirrhosis. Bile acids grow the risk of injury and fibrosis to the injured bile ducts. Ocanat 5mg tablet is an agonist for FXR, a nuclear receptor indicates in the liver and intestine. FXR is a key manager of bile acid, inflammatory, fibrotic, and metabolic pathways. FXR energizing loss of intracellular hepatocyte absorption of bile acids by overcoming de novo combining from cholesterol as well as by high transport of bile acids out of the hepatocytes.

Pharmacokinetics:

1. Absorption

Ocanat 5mg tablet is involved in the gastrointestinal tract. The Cmax of Ocanat 5mg tablet appears at almost 1.5 hours after an oral dose and domain from 28.8-53.7 ng/mL at doses of 5-10mg. The median Tmax for both has been combined with Ocanat 5mg tablet is about 10 hours.

2. Distribution

The volume of the distribution of Ocanat 5mg tablet is 618 L.

3. Metabolism

The metabolism of Ocanat 5mg tablet appears in the liver. Ocanat 5mg tablet is combined with glycine or taurine, followed by excretion into bile. The combines are then consumed in the small intestine and then re-enter the liver via enterohepatic distribution.

4. Excretion

About 87% of an orally administrate dose is supposed for in the feces. Less than 3% of the dose can be recovered in the urine.

The biological half-life of the Ocanat 5mg tablet is reported to be 24 hours.

Dosage and Administration:

The suggested starting dose of Ocanat 5mg tablet is 5 mg once weekly for patients with Child-Pugh Class B or C hepatic breakage or a previous decompensating action.

Drug Interaction:

Drug interactions may variation how your treatment effort or growth your risk for severe side effects.

Side-Effects:

·        Tiredness, 

·        Throat pain, or

·        Pounding heartbeat may appear,

·        Skin itching, 

·        Nausea,

·        Loss of appetite, 

·        Abdominal pain,

·        Yellowing eyes, 

·        Dark urine,

·        Joint pain,

·        Abdomen, or

·        Mental

Uses:

This treatment of Ocanat 5mg tablet is used apart or in mixture treatment for secure liver disease (primary biliary cholangitis-PBC). This infection gently damages the bile ducts in the liver.

Contraindication:

Ocanat 5mg tablet is contraindicated in patients with determining biliary impediment.

Adverse Reactions:

·        Hepatic Decompensating and breakdown in wrongly dosed PBC Patients with Child-Pugh Class B or C or Decompensated Cirrhosis

·        Liver-similar Adverse response

·        Serious Pruritus

·        Rebate in HDL-C

Storage:

Store at 20^oC-25^oC (68^oF-77^oF) a room temperature.

Contact details Apple Pharmaceuticals Mobile/Viber/Telegram :+919987711567WeChat : applepharmaceuticals Skype : applepharmaqq : 2097734872Email id :applepharmaceutical@gmail.comWebsite : https://myapplepharma.com/