Favivir 200MG TABLETS
Favivir is an antiviral medicine. Favivir is used for the
treatment of Influenza. Favivir is a pyrazine carboxamide derivative like
(T-1105 & T-1106). Favivir is also being studied and used to treat a number
of other viral infections. It became a common drug.
Mechanism of action:
The mechanism of action is thought to be combined with the
selective inhibition of viral RNA-dependent RNA polymerase. Other research
suggests that Favivir induces lethal RNA transversion mutations, producing an
unwise viral phenotype. Favivir is a prodrug that is used to metabolize an
active form, favipiravir-ribofuranosyl-5'-triphosphate (Favipiravir-RTP),
available in both oral and intravenous formulations. Human hypoxanthine-guanine
phosphoribosyltransferase (HGPRT) is treated to play a key role in this
activation process. Favivir does not prevent RNA or DNA synthesis in mammalian
cells and is not toxic to them. However, Favivir has not been shown to be
active in primary human airway cells, casting doubt on its potency in influenza
treatment.
Drug Interaction
Favivir inhibited irreversibly AO in a dose and
time-dependent manner and inhibited CYP2C8 in a dose-dependent manner. There
was no inhibitory action to XO, and weak inhibitory movement to CYP1A2. The
hydroxylase metabolite showed weak inhibitory action to CYP1A2. The inductive effect of Favivir on CYP was not recognized.
PHARMACOKINETICS
1. Absorption
When Favivir was given as a single dose of 400 mg with food, the Cmax reduced. It develops
that Favivir is given at a higher dose or in multiple doses, irreversible
inhibition of aldehyde oxidase (AO) appear and the effect of food on the Cmax
is lower.
2. Distribution
Favivir is a the antibody-protein binding ratio was 53.4 to 54.4% (Centrifugal ultrafiltration)
at 0.3 - 30 μg/ml.
3. Metabolism
Favivir was not
metabolized by cytochrome P-450 (CYP), mainly metabolized by aldehyde oxidase
(AO), and slightly metabolized to a hydroxylated form by xanthine oxidase (XO).
4. Excretion
Favivir was mainly secreted as a hydroxylated form into the
urine 0.8% and little amount of unaffected drug 53.1% were noticed. The half-life of Favivir is concluded to range from 2 to 5.5 hours.
Uses:
Favivir is determined for novel influenza (strains that
cause more severe disease) rather than recurring influenza.
Side Effects:
Recommended not to use during pregnancy because its
impairment to the baby
Contraindications
There are several contraindications when using Favivir tablets. In the history of patients is a hypersensitivity to any ingredient of
a drug.
Pregnancy and Lactation
·
No breastfeeding is suggested
Storage:
Favivir tablets capsule should be stocked at room the temperature at below 30℃(86 ℉) Favivir container should be kept
away from humidity, warmth, and sun
Dosage and Administration
The Common dose of Favivir for adults is 1600 mg orally
twice in a day replace by 600 mg orally twice for 4 days. The total composition
time should be for 5 days.
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FAVIVIR 200MG |
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