Tuesday, June 23, 2020

FAVIPIRAVIR 200mg TABLETS

FAVIPIRAVIR 200mg TABLETS


 

Fabiflu is an antiviral medicine. Fabiflu is used for the treatment of Influenza. Fabiflu is a pyrazine carboxamide derivative like (T-1105 & T-1106). Fabiflu is also being studied and used to treat a number of other viral infections. It became a common drug.

Mechanism of action:

The mechanism of action is thought to be combined with the selective inhibition of viral RNA-dependent RNA polymerase. Other research suggests that Fabiflu induces lethal RNA transversion mutations, producing an unwise viral phenotype. Fabiflu is a prodrug that is used to metabolize an active form, Fabiflu-ribofuranosyl-5'-triphosphate (Fabiflu-RTP), available in both oral and intravenous formulations. Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is treated to play a key role in this activation process. Fabiflu does not prevent RNA or DNA synthesis in mammalian cells and is not toxic to them. However, Fabiflu has not been shown to be active in primary human airway cells, casting doubt on its potency in influenza treatment.

Drug Interaction

Fabiflu inhibited irreversibly AO in a dose and time-dependent manner and inhibited CYP2C8 in a dose-dependent manner. There was no inhibitory action to XO, and weak inhibitory movement to CYP1A2. The hydroxylase metabolite showed weak inhibitory action to CYP1A2. Inductive effect of Fabiflu on CYP was not recognized.

PHARMACOKINETICS

1. Absorption

       When Fabiflu was given as a single dose of 400 mg with food, the Cmax reduced. It develops that Fabiflu is given at a higher dose or in multiple doses, irreversible inhibition of aldehyde oxidase (AO) appear and the effect of food on the Cmax is lower.

2. Distribution

         Fabiflu is an antibody protein binding ratio was 53.4 to 54.4% (Centrifugal ultrafiltration) at 0.3 - 30 μg/ml.

3. Metabolism

   Fabiflu was not metabolized by cytochrome P-450 (CYP), mainly metabolized by aldehyde oxidase (AO), and slightly metabolized to a hydroxylated form by xanthine oxidase (XO).

4. Excretion

Fabiflu was mainly secreted as a hydroxylated form into the urine 0.8% and little amount of unaffected drug 53.1% was noticed. The half-life of Fabiflu is concluded to range from 2 to 5.5 hours.

Uses:

Fabiflu is determined for novel influenza (strains that cause more severe disease) rather than recurring influenza.

Side Effects:

Recommended not to use during pregnancy because its impairment to the baby

Contraindications

There are several contraindications when using Fabiflu tablets. In the history of patients is a hypersensitivity to any ingredient of a drug.

Pregnancy and Lactation

·        Fabiflu should not be used in a Pregnancy situation

·        No breastfeeding is suggested

Storage:

Fabiflu tablets capsule should be stocked at room temperature at below 30(86 ) Fabiflu container should be kept away from humidity, warmth, and sun

Dosage and Administration

The Common dose of Fabiflu for adults is 1600 mg orally twice in a day replace by 600 mg orally twice for 4 days. The total composition time should be for 5 days.

Contact details 
Apple Pharmaceuticals 
Mobile/Viber/Telegram:+919987711567
WeChat: applepharmaceuticals 
Skype: applepharma
qq: 2097734872
Email id:applepharmaceutical@gmail.com


FABIFLU 200MG TABLET

FABIFLU 200MG TABLET

 

Fabiflu is an antiviral medicine. Fabiflu is used for the treatment of Influenza. Fabiflu is a pyrazine carboxamide derivative like (T-1105 & T-1106). Fabiflu is also being studied and used to treat a number of other viral infections. It became a common drug.

Mechanism of action:

The mechanism of action is thought to be combined with the selective inhibition of viral RNA-dependent RNA polymerase. Other research suggests that Fabiflu induces lethal RNA transversion mutations, producing an unwise viral phenotype. Fabiflu is a prodrug that is used to metabolize an active form, Fabiflu-ribofuranosyl-5'-triphosphate (Fabiflu-RTP), available in both oral and intravenous formulations. Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is treated to play a key role in this activation process. Fabiflu does not prevent RNA or DNA synthesis in mammalian cells and is not toxic to them. However, Fabiflu has not been shown to be active in primary human airway cells, casting doubt on its potency in influenza treatment.

Drug Interaction

Fabiflu inhibited irreversibly AO in a dose and time-dependent manner and inhibited CYP2C8 in a dose-dependent manner. There was no inhibitory action to XO, and weak inhibitory movement to CYP1A2. The hydroxylase metabolite showed weak inhibitory action to CYP1A2. Inductive effect of Fabiflu on CYP was not recognized.

PHARMACOKINETICS

1. Absorption

       When Fabiflu was given as a single dose of 400 mg with food, the Cmax reduced. It develops that Fabiflu is given at a higher dose or in multiple doses, irreversible inhibition of aldehyde oxidase (AO) appear and the effect of food on the Cmax is lower.

2. Distribution

         Fabiflu is an antibody protein binding ratio was 53.4 to 54.4% (Centrifugal ultrafiltration) at 0.3 - 30 μg/ml.

3. Metabolism

   Fabiflu was not metabolized by cytochrome P-450 (CYP), mainly metabolized by aldehyde oxidase (AO), and slightly metabolized to a hydroxylated form by xanthine oxidase (XO).

4. Excretion

Fabiflu was mainly secreted as a hydroxylated form into the urine 0.8% and little amount of unaffected drug 53.1% was noticed. The half-life of Fabiflu is concluded to range from 2 to 5.5 hours.

Uses:

Fabiflu is determined for novel influenza (strains that cause more severe disease) rather than recurring influenza.

Side Effects:

Recommended not to use during pregnancy because its impairment to the baby

Contraindications

There are several contraindications when using Fabiflu tablets. In the history of patients is a hypersensitivity to any ingredient of a drug.

Pregnancy and Lactation

           Fabiflu should not be used in a Pregnancy situation

           No breastfeeding is suggested

Storage:

Fabiflu tablets capsule should be stocked at room temperature at below 30(86 ) Fabiflu container should be kept away from humidity, warmth, and sun

Dosage and Administration

The Common dose of Fabiflu for adults is 1600 mg orally twice in a day replace by 600 mg orally twice for 4 days. The total composition time should be for 5 days.



Contact details 
Apple Pharmaceuticals 
Mobile/Viber/Telegram:+919987711567
WeChat: applepharmaceuticals 
Skype: applepharma
qq: 2097734872
Email id:applepharmaceutical@gmail.com

AFANAT 20MG/30MG/40MG


AFANAT 20MG/30MG/40MG

Wednesday, June 17, 2020

FAVIVIR 200MG TABLETS

Favivir  200MG TABLETS


Favivir is an antiviral medicine. Favivir is used for the treatment of Influenza. Favivir is a pyrazine carboxamide derivative like (T-1105 & T-1106). Favivir is also being studied and used to treat a number of other viral infections. It became a common drug.
Mechanism of action:
The mechanism of action is thought to be combined with the selective inhibition of viral RNA-dependent RNA polymerase. Other research suggests that Favivir induces lethal RNA transversion mutations, producing an unwise viral phenotype. Favivir is a prodrug that is used to metabolize an active form, favipiravir-ribofuranosyl-5'-triphosphate (Favipiravir-RTP), available in both oral and intravenous formulations. Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is treated to play a key role in this activation process. Favivir does not prevent RNA or DNA synthesis in mammalian cells and is not toxic to them. However, Favivir has not been shown to be active in primary human airway cells, casting doubt on its potency in influenza treatment.
Drug Interaction
Favivir inhibited irreversibly AO in a dose and time-dependent manner and inhibited CYP2C8 in a dose-dependent manner. There was no inhibitory action to XO, and weak inhibitory movement to CYP1A2. The hydroxylase metabolite showed weak inhibitory action to CYP1A2. The inductive effect of Favivir on CYP was not recognized.
PHARMACOKINETICS
1. Absorption
When Favivir was given as a single dose of 400 mg with food, the Cmax reduced. It develops that Favivir is given at a higher dose or in multiple doses, irreversible inhibition of aldehyde oxidase (AO) appear and the effect of food on the Cmax is lower.
2. Distribution
Favivir is a the antibody-protein binding ratio was 53.4 to 54.4% (Centrifugal ultrafiltration) at 0.3 - 30 μg/ml.
3. Metabolism
Favivir was not metabolized by cytochrome P-450 (CYP), mainly metabolized by aldehyde oxidase (AO), and slightly metabolized to a hydroxylated form by xanthine oxidase (XO).
4. Excretion
Favivir was mainly secreted as a hydroxylated form into the urine 0.8% and little amount of unaffected drug 53.1% were noticed. The half-life of Favivir is concluded to range from 2 to 5.5 hours.
Uses:
Favivir is determined for novel influenza (strains that cause more severe disease) rather than recurring influenza.
Side Effects:
Recommended not to use during pregnancy because its impairment to the baby
Contraindications
There are several contraindications when using Favivir tablets. In the history of patients is a hypersensitivity to any ingredient of a drug.
Pregnancy and Lactation
·        Favivir should not be used in a Pregnancy situation
·        No breastfeeding is suggested
Storage:
Favivir tablets capsule should be stocked at room the temperature at below 30(86 ) Favivir container should be kept away from humidity, warmth, and sun
Dosage and Administration
The Common dose of Favivir for adults is 1600 mg orally twice in a day replace by 600 mg orally twice for 4 days. The total composition time should be for 5 days.

Contact details
Apple Pharmaceuticals
Mobile/Viber/Telegram :+919987711567
WeChat : applepharmaceuticals
Skype : applepharma
qq : 2097734872
Email id :applepharmaceutical@gmail.com
Website : https://myapplepharma.com/

FAVIVIR 200MG TABLETS

OCANAT 10mg

OCANAT 10mg 

Sunday, June 7, 2020

OCANAT TABLET


Ocanat 5mg tablet is a semi-synthetic bile acid analog that has the chemical formation of 6α-ethyl-chenodeoxycholic acid. Ocanat 5mg tablet is used as a medicine to treatment basic biliary cholangitis and is sustain with growth for various other liver diseases and similar disorders.
Mechanism of action:
Primary biliary cirrhosis is an auto resistant action by which the bile ducts and liver are injured more, dominant to fibrosis and cirrhosis. Bile acids grow the risk of injury and fibrosis to the injured bile ducts. Ocanat 5mg tablet is an agonist for FXR, a nuclear receptor indicates in the liver and intestine. FXR is a key manager of bile acid, inflammatory, fibrotic, and metabolic pathways. FXR energizing loss of intracellular hepatocyte absorption of bile acids by overcoming de novo combining from cholesterol as well as by high transport of bile acids out of the hepatocytes.
Pharmacokinetics:
1. Absorption
Ocanat 5mg tablet is involved in the gastrointestinal tract. The Cmax of Ocanat 5mg tablet appears at almost 1.5 hours after an oral dose and domain from 28.8-53.7 ng/mL at doses of 5-10mg. The median Tmax for both has been combined with Ocanat 5mg tablet is about 10 hours.
2. Distribution
The volume of the distribution of Ocanat 5mg tablet is 618 L.
3. Metabolism
The metabolism of Ocanat 5mg tablet appears in the liver. Ocanat 5mg tablet is combined with glycine or taurine, followed by excretion into bile. The combines are then consumed in the small intestine and then re-enter the liver via enterohepatic distribution.
4. Excretion
About 87% of an orally administrate dose is supposed for in the feces. Less than 3% of the dose can be recovered in the urine.
The biological half-life of the Ocanat 5mg tablet is reported to be 24 hours.
Dosage and Administration:
The suggested starting dose of Ocanat 5mg tablet is 5 mg once weekly for patients with Child-Pugh Class B or C hepatic breakage or a previous decompensating action.
Drug Interaction:
Drug interactions may variation how your treatment effort or growth your risk for severe side effects.
Side-Effects:
·        Tiredness, 
·        Throat pain, or
·        Pounding heartbeat may appear,
·        Skin itching, 
·        Nausea,
·        Loss of appetite, 
·        Abdominal pain,
·        Yellowing eyes, 
·        Dark urine,
·        Joint pain,
·        Abdomen, or
·        Mental
Uses:
This treatment of Ocanat 5mg tablet is used apart or in mixture treatment for secure liver disease (primary biliary cholangitis-PBC). This infection gently damages the bile ducts in the liver.
Contraindication:
Ocanat 5mg tablet is contraindicated in patients with determining biliary impediment.
Adverse Reactions:
·        Hepatic Decompensating and breakdown in wrongly dosed PBC Patients with Child-Pugh Class B or C or Decompensated Cirrhosis
·        Liver-similar Adverse response
·        Serious Pruritus
·        Rebate in HDL-C
Storage:
Store at 20oC-25oC (68oF-77oF) a room temperature.

Contact details Apple Pharmaceuticals Mobile/Viber/Telegram :+919987711567WeChat : applepharmaceuticals Skype : applepharmaqq : 2097734872Email id :applepharmaceutical@gmail.comWebsite : https://myapplepharma.com/

Favivir 200MG TABLETS


Favivir  200MG TABLETS


Favivir is an antiviral medicine. Favivir is used for the treatment of Influenza. Favivir is a pyrazine carboxamide derivative like (T-1105 & T-1106). Favivir is also being studied and used to treat a number of other viral infections. It became a common drug.
Mechanism of action:
The mechanism of action is thought to be combined with the selective inhibition of viral RNA-dependent RNA polymerase. Other research suggests that Favivir induces lethal RNA transversion mutations, producing an unwise viral phenotype. Favivir is a prodrug that is used to metabolize an active form, favipiravir-ribofuranosyl-5'-triphosphate (Favipiravir-RTP), available in both oral and intravenous formulations. Human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is treated to play a key role in this activation process. Favivir does not prevent RNA or DNA synthesis in mammalian cells and is not toxic to them. However, Favivir has not been shown to be active in primary human airway cells, casting doubt on its potency in influenza treatment.
Drug Interaction
Favivir inhibited irreversibly AO in a dose and time-dependent manner and inhibited CYP2C8 in a dose-dependent manner. There was no inhibitory action to XO, and weak inhibitory movement to CYP1A2. The hydroxylase metabolite showed weak inhibitory action to CYP1A2. The inductive effect of Favivir on CYP was not recognized.
PHARMACOKINETICS
1. Absorption
When Favivir was given as a single dose of 400 mg with food, the Cmax reduced. It develops that Favivir is given at a higher dose or in multiple doses, irreversible inhibition of aldehyde oxidase (AO) appear and the effect of food on the Cmax is lower.
2. Distribution
Favivir is a the antibody-protein binding ratio was 53.4 to 54.4% (Centrifugal ultrafiltration) at 0.3 - 30 μg/ml.
3. Metabolism
Favivir was not metabolized by cytochrome P-450 (CYP), mainly metabolized by aldehyde oxidase (AO), and slightly metabolized to a hydroxylated form by xanthine oxidase (XO).
4. Excretion
Favivir was mainly secreted as a hydroxylated form into the urine 0.8% and little amount of unaffected drug 53.1% were noticed. The half-life of Favivir is concluded to range from 2 to 5.5 hours.
Uses:
Favivir is determined for novel influenza (strains that cause more severe disease) rather than recurring influenza.
Side Effects:
Recommended not to use during pregnancy because its impairment to the baby
Contraindications
There are several contraindications when using Favivir tablets. In the history of patients is a hypersensitivity to any ingredient of a drug.
Pregnancy and Lactation
·        Favivir should not be used in a Pregnancy situation
·        No breastfeeding is suggested
Storage:
Favivir tablets capsule should be stocked at room the temperature at below 30(86 ) Favivir container should be kept away from humidity, warmth, and sun
Dosage and Administration
The Common dose of Favivir for adults is 1600 mg orally twice in a day replace by 600 mg orally twice for 4 days. The total composition time should be for 5 days.

Contact details
Apple Pharmaceuticals
Mobile/Viber/Telegram :+919987711567
WeChat : applepharmaceuticals
Skype : applepharma
qq : 2097734872
Email id :applepharmaceutical@gmail.com
Website : https://myapplepharma.com/

FAVIVIR 200MG 


OCANAT TABLET


OCANAT TABLET

Ocanat 10mg tablet is a semi-synthetic bile acid analog that has the chemical formation of 6α-ethyl-chenodeoxycholic acid. Ocanat 10mg tablet is used as a medicine to treatment basic biliary cholangitis and is sustain with growth for various other liver diseases and similar disorders.
Mechanism of action:
Primary biliary cirrhosis is an auto resistant action by which the bile ducts and liver are injured more, dominant to fibrosis and cirrhosis. Bile acids grow the risk of injury and fibrosis to the injured bile ducts. Ocanat 10mg tablet is an agonist for FXR, a nuclear receptor indicates in the liver and intestine. FXR is a key manager of bile acid, inflammatory, fibrotic, and metabolic pathways. FXR energizing loss of intracellular hepatocyte absorption of bile acids by overcoming de novo combining from cholesterol as well as by high transport of bile acids out of the hepatocytes.
Pharmacokinetics:
1. Absorption
Ocanat 10mg tablet is involved in the gastrointestinal tract. The Cmax of Ocanat 10mg tablet appears at almost 1.5 hours after an oral dose and domain from 28.8-53.7 ng/mL at doses of 5-10mg. The median Tmax for both has been combined with Ocanat 10mg tablet is about 10 hours.
2.            Distribution
The volume of the distribution of Ocanat 10mg tablet is 618 L.
3.            Metabolism
The metabolism of Ocanat 10mg tablet appears in the liver. Ocanat 10mg tablet is combined with glycine or taurine, followed by excretion into bile. The combines are then consumed in the small intestine and then re-enter the liver via enterohepatic distribution.
4.            Excretion
About 87% of an orally administrate dose is supposed for in the feces. Less than 3% of the dose can be recovered in the urine.
The biological half-life of the Ocanat 10mg tablet is reported to be 24 hours.
Dosage and Administration:
The suggested starting dose of Ocanat 10mg tablet is 5 mg once weekly for patients with Child-Pugh Class B or C hepatic breakage or a previous decompensating action.
Drug Interaction:
Drug interactions may variation how your treatment effort or growth your risk for severe side effects.
Side-Effects:
·        Tiredness, 
·        Throat pain, or
·        Pounding heartbeat may appear,
·        Skin itching, 
·        Nausea,
·        Loss of appetite, 
·        Abdominal pain,
·        Yellowing eyes, 
·        Dark urine,
·        Joint pain,
·        Abdomen, or
·        Mental
Uses:
This treatment of Ocanat 10mg tablet is used apart or in mixture treatment for secure liver disease (primary biliary cholangitis-PBC). This infection gently damages the bile ducts in the liver.
Contraindication:
Ocanat 10mg tablet is contraindicated in patients with determining biliary impediment.
Adverse Reactions:
·        Hepatic Decompensating and breakdown in wrongly dosed PBC Patients with Child-Pugh Class B or C or Decompensated Cirrhosis
·        Liver-similar Adverse response
·        Serious Pruritus
·        Rebate in HDL-C
Storage:
Store at 20oC-25oC (68oF-77oF) a room temperature.

Contact details
Apple Pharmaceuticals
Mobile/Viber/Telegram :+919987711567
WeChat : applepharmaceuticals
Skype : applepharma
qq : 2097734872
Email id :applepharmaceutical@gmail.com
Website : https://myapplepharma.com/



Friday, June 5, 2020


Corona Virus Disease (COVID-19)

Coronavirus disease2019 (COVID-19) is a spreading disease that begins with serious acute respiratory disease coronavirus 2 (SARS-CoV-2). It was first established in December 2019 in Wuhan, China, and has resulted in an ongoing pandemic. The first patient may be traced back to 17 November 2019. As of 5 June 2020, more than 6.6 million cases have been recorded across 188 countries and territories, appearing in more than 389,000 deaths. More than 2.85 million people have been recovered. [1]
The common symptoms of COVID-19 are fever, tiredness, breathing problem, diarrhea, loss of smell, and taste. During most of the cases issued in mild symptoms are some processes to acute respiratory distress syndrome (ARDS) likely further by a cytokine storm, multi-organ failure, septic shock, and blood clots. The time from risk to the beginning of symptoms is generally over five days but may extend from two to fourteen days. Day to day symptoms of COVID-19 before the person is coughing in your face but your initial judgment only. If you are not feeling well you should meet a medical examiner and to accurate diagnosis and proper treatment of COVID-19. [2] These symptoms are severed into
Day 1-2: the beginning symptoms are similar to the common cold and mild sore fort having a fever no feeling tired them taking food and drink usually.
Day-3: The patient's throat still feels about painful body temperature reads about 36.5oC. There is a common symptom is Vomiting, Nausea & Diarrhea.
Day-4: Throat pain becomes more serious pain the symptoms of feeling weak and joint pains will be manifest, the patient may raising the temperature between 36.5o to 37oC.
Day 5-6: The patient gets mild fever starts them raising the temperature to 37.3oC & the second most common symptom is dry cough also appears dissimilar to breathing too difficult may occur.  Most of the patients in this stage are feeling tired of the symptoms remind about the same.
According to the final report of china was an initial the outbreak of COVID-19 they conduct the joint mission of china and WHO.
Day-7: The patient’s start to more severe coughing difficulty fever is higher up to 38oC. The patients may develop a headache and body pain in over diarrhea.
Many patients have to admitted to hospital in this stage
Day 8-9: The symptoms of the patients are likely worse to the difficulty of breathing who’s having the medical condition of co-existence sebaceous gland becomes breath more frequent the temperature raises the 38oC. Day 9 is the average time when upset the still effects of 40% in patients.
Day10-11:  Doctors awaking to intimate like chest to capture the severity of the respiratory distract in patients. The patients having a loss of appetite & may face abdominal pain. The condition also needs immediate treatment of ICU.
Day12-14: For the survivor, symptoms can be well managed to the point. Fever can better to normal degree & breathing difficulty is better. But some patients may be still affected by the mild cough.
Day15-16: Day 15 is the opposite condition for the rest of the minority patients. The forage patient must be a possibility of cured cardiac injury or kidney injury
Day17-19: Covid-19 affects fatality cases. Before the time the vulnerable patients may develop a secondary infection caused by a pathogen in a lower respiratory tract. The condition leads to blood coagulation and then schemed. [3]
What are the foods eating in the corona period?
·        Water Drinks a lot of water hydration is incredibly important because the water for all cell either functioning make a sure if you’re a woman 2Litres water per day & men 3litres Per Day.
·        Next, certain fruits can be boosting your immune system.
·        Berries are the rich in antioxidants & a great source of vitamin C. Blackberries are the resveratrol for your immune system.
·        Almond is a protein, fibers & Vitamin E for the immune function.
·        Garlic and Onion knew for the entire oxidant capabilities as well as antimicrobial capabilities.
·        Fish is highly recommended omega-3 fatty acids, proteins, and minerals for all of your body’s functions.
·        The egg is having so many choline & vitamins, minerals are there an incredible source of protein.[4]
5 Best ways to prevent the COVID-19
·        Clean your hands regularly. Use soap and water, or an ethanol-based hand brushing.
·        Keep a safe distance from everybody who is coughing or sneezing.
·        Don’t touch your eyes, nose, or mouth.
·        Mask your nose and mouth with your bent elbow or a tissue when you cough or sneeze.
·        Stay home if you feel sick.
Don’t Skip on Exercise
A great diet should be followed by an exercise every day. Remind to exercise every day; balance light exercise will go a long way in clearing the toxins from your body. It is suggested to exercise for 30 to 45 minutes, depending on your strength. Everyday exercise develops metabolism, which has a direct interaction with body immunity.
Avoid Smoking, alcohol and other addictive substances
A secure manner like smoking, vaping, alcohol utilization, and object offense has a direct interaction between weak body defenses and respiratory disease. Captivating in smoking and vaping is determined to weaken your lung quantity and damage the cells covering your respiratory tracts, these cells are important to fight viruses that enter over your nasal opening. There is new research defending that thing the uses in heavy alcohol use contribute to suffering from ARDS (Acute Respiratory distress syndrome) which is one of the circumstances induce by COVID 19 disease.[]
Turmeric and Garlic
The bright yellow spice, Turmeric, includes a combined called curcumin, which supports the immune function.
Apart from managing a healthy lifestyle and making improvements, the Indian health ministry is also indicating few organic and natural ways to practice as a defending part to fight COVID-19. The Ministry of AYUSH has suggested the following self-care guidance as a preventive area and to boost protection with a special allusion to the respiratory state.
·        Drink hot water during the day.
·        Practice Meditation, Yogasana, and Pranayama.
·        Growth of absorption of Turmeric, Cumin, Coriander, and garlic.
·        Drink herbal tea or liquid of Holy basil, Cinnamon, Black pepper, Dry Ginger, and Raisin.
·        Prevent sugar and replace it with jaggery if wanted.
·        Apply Ghee (clarified butter), Sesame oil, or Coconut oil in both the nostrils to keep the nostrils clean.
·        Puff steam with Mint flees and Caraway seeds.[5]
References:
  1. 1https://en.wikipedia.org/wiki/Coronavirus_disease_2019
  2. 2Symptoms of corona
  3. 3https://www.youtube.com/watch?v=U8r3oTVMtQ0
  4. (FreeMedEducation)
  5. 4https://www.youtube.com/watch?v=g0RMPyAZyjE (inside edition)
  6. 5https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public (WHO)


Thursday, June 4, 2020

VIROPIL TABLET

VIROPIL TABLET

Viropil is a drug used to treat HIV/AIDS. Viropil is a mixture of Dolutegravir, lamivudine, and tenofovir disoproxil. The human immunodeficiency virus (HIV) multiplies in cells of the resistant organization and damages them. Without proper medication, the immune system of most HIV patients is tired so much over an era that they convert actively diseased.
Mechanism of action:
Dolutegravir is an HIV-1 antiviral agent. Viropil prevents HIV integrase by covering to the effective place of activity and obstructing the string conduction step of retroviral DNA unification in performs cell. The string conduction step is a condition in the HIV reproduction cycle and development in the prevention of viral action. Lamivudine is an artificial nucleoside analog and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside parallel is included in viral DNA by HIV reverse transcriptase and HBV polymerase, developing in DNA chain termination. Tenofovir exists to consider antiretroviral medicine known as nucleotide analog reverse transcriptase inhibitors (NtRTIs), which prevent reverse transcriptase, an enzyme required for viral management in HIV-infected thing. This implements the administration of HIV viral load over reduce viral reproduction.
Pharmacokinetics:
1. Absorption
When 50 mg of Dolutegravir once every day was orally carried out to HIV-1 affect person, the AUC, Cmax, and Cmin is 53.6 mcg h/mL, 3.67mcg/mL, and 1.11mcg/mL, commonly. The peak plasma combination was recognized 2 to 3 hours post-dose. Lamivudine was immediately involved after oral administration in HIV-diseased patients. After oral carry out of tenofovir disoproxil to patients with HIV disease, tenofovir disoproxil is rapidly involved and metabolized to tenofovir.
2. Distribution
The conducting of a dose of 50 mg of Dolutegravir instant a seeming volume of distribution is 17.4 L. Volume of distribution was separated to dose and did not compare with body pressure. The volume of distribution at fixed-state is 1.3 ± 0.6 L/kg and 1.2 ± 0.4 L/kg, following intravenous direction of tenofovir 1.0 mg/kg and 3.0 mg/kg
3. Metabolism
Metabolism of lamivudine is an underage route of eradication. Dolutegravir is deeply metabolized over three main pathways and it forms no deep-aware metabolites. The first pathway is described by the glucuronidation by UGT1A1, the second pathway by carbon oxidation by CYP3A4 and the third pathway is what develops to be a subsequent oxidative defluorination and glutathione combination. Tenofovir disoproxil fumarate is the fumarate flavoring of the prodrug tenofovir disoproxil.
    4. Excretion
Dolutegravir is almost all total doses are recovered in a capacity of 53% excreted unaffected in the feces and 31% excreted in the urine. The mot of lamivudine is removed unchanged in the urine by the effective natural cationic flow. Tenofovir nearly 70–80% of the dose is found in the urine as constant tenofovir within 72 hours of treatment.
Side-Effects:
Viropil  is side effects that may contain trouble sleeping, weight gain, and rash.
Dosage and Administration:
Viropil  is a suggested dosage procedure of Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablets is one tablet once every day carried out.
Contraindication:
Viropil  is a Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablets are contraindicated in patients with preceding hypersensitivity response.
Storage:
Store in a Dry place Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablets in the original container, protect from humidity and keep the bottle tightly closed.
Pregnancy & Lactation:
There is a pregnancy uncovering archives that oversee pregnancy effect in women unprotected to Dolutegravir, lamivudine, and tenofovir disoproxil fumarate tablets during pregnancy
HIV-1 disease is not to breastfeed because HIV-1 can be developing to the baby in breast milk.

Contact details 
Apple Pharmaceuticals 
Mobile/Viber/Telegram :+919987711567
WeChat : applepharmaceuticals 
Skype : applepharma
qq : 2097734872
Email id:applepharmaceutical@gmail.com
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TAFFIC TABLET


Taffic tablet is determined as an entire procedure for the medication of human immunodeficiency virus type 1 (HIV-1) infection who has no antiretroviral medication history or to follow the common antiretroviral procedure in those who are virologically-contain on a stable antiretroviral procedure.  Taffic tablet is a permanent dose of mixture medicine for the medication of HIV/AIDS. It consists of 50 mg bictegravir, 200 mg emtricitabine, and 25 mg tenofovir alafenamide.

Mechanism of action:

Bictegravir: BIC prevents the string transfer action of HIV-1 integrase (integrase string transfer prevents; INSTI), an HIV-1 encoded enzyme that is recommended for viral reproduction. Prevention of integrase inhibits the integration of linear HIV-1 DNA into host genomic DNA; prevent the formation of the HIV-1 provirus and reproduction of the virus.
Emtricitabine: FTC is an artificial nucleoside bride of cytidine, is phosphorylated by a cellular stimulant to form emtricitabine 5'-triphosphate. Emtricitabine 5'-triphosphate prevents the action of the HIV-1 reverse transcriptase by contending with the natural substrate deoxycytidine 5'-triphosphate and by actually included in nascent viral DNA which results in chain termination. Emtricitabine 5′-triphosphate is a weak preventer of mammalian DNA polymerases α, β, Ɛ, and mitochondrial DNA polymerase.
Tenofovir Alafenamide: TAF is a phosphoramidite prodrug of tenofovir (2′-deoxyadenosine monophosphate analog). Plasma revelation to TAF admits for transport into cells and then TAF is intracellularly transformed to tenofovir through hydrolysis by cathepsin A. Tenofovir is finally phosphorylated by cellular kinases to the effective metabolite tenofovir diphosphate. Tenofovir diphosphate prevents HIV-1 reproduction through fusion into viral DNA by the HIV reverse transcriptase, which development in DNA chain-termination. Tenofovir diphosphate is a weak preventer of mammalian DNA polymerases that contain mitochondrial DNA polymerase γ and there is no information of toxicity to mitochondria in cell cultivation.
Pharmacokinetics:
1. Absorption
Taffic tablet rapidly absorbed to the body is Tmax is 2.0-4.0hrs, 1.5–2.0 hrs, and 0.5–2.0 hrs. Then Cmax ration is 1.13, 0.86, and 0.92.
2. Distribution
Taffic tablet is the volume of distribution in the blood to plasma ratio is 0.64L, 0.6L, and 1.0L.
3. Metabolism
Emtricitabine is almost 86% unmetabolized. The average half-life of BIC estimated from 15.9 h - 20.9 h. Tenofovir alafenamide is recommended to be determined to the person associate tenofovir by the action of cathepsin A or carboxylesterase 1.
4. Excretion
Taffic tablet is the excretion of the dose is recovered from the urine is 70% & the excretion of the dose is recovered from the feces is 60.3%.
Storage:
Store in a Dry place 30°C (86°F).
• Keep bottle tightly closed.
 Dispense only in the original bottle.
Dosage and Administration:
The suggested dose of Taffic tablet is one tablet taken orally once every day with or without food.
CONTRAINDICATIONS:
 Taffic tablet is contraindicated to be co-conduct with dofetilide expected to the possible for raised dofetilide plasma combination and combine severe and life-aggressive events.
Side-Effects:
The common side effects of Taffic tablet are Depression
Abnormal dreams, Headache, Dizziness, Diarrhea, Feeling sick (nausea), Tiredness (fatigue).
Overdosage:
Hemodialysis medication eliminates almost 30% of the FTC dose over a 3-hour separation time starting within 1.5 hours of FTC dosing (blood flow rate of 400 mL per minute and a dialysate flow rate of 600 mL per minute).


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